The fact that we are coming up on a month of Fable being unavailable with essentially zero actual signal from Anthropic around when it may be back is crazy to me. Yet still we have these random new products coming out?
> Anthropic @AnthropicAI Jun 27, 2026 · 12:29 AM UTC
> Since June 12, we’ve been working closely with the US government to restore access to Claude Mythos 5 and Fable 5. Today, the government notified us that Mythos 5, our strongest cybersecurity model, can be redeployed to a set of US organizations that operate and defend critical infrastructure.
> We’re restoring access for these organizations quickly, and we’re continuing to work with the government to expand access to Mythos 5 and make Fable 5 available for general use again.
ianm218•Jun 30, 2026
I mean the company has like 3k employees or more right? Lots of them are just working on more applied AI use cases that don't require frontier AI just the right integrations and structure etc.
Opus 4.8/ GPT 5.6 level models with the right workflows/ data/ access are still good enough to do huge amounts of economically valueable work.
bigyabai•Jun 30, 2026
How about no?
AI brand identity has made the unfortunate pivot to "how much do you trust us" which is going be a real race to the bottom. I don't want LLMs managing nuclear reactors or replacing junior lab technicians. I don't trust any of these LLMs to do the bare minimum, regardless of how good it is for your brand.
It's gross watching these stunts unfold. Next ChatGPT will fly a passenger jet, which Claude will one-up with an agentic surgery, which OpenAI will respond to by putting a humanoid robot on the moon. If this is what 21st century market competition looks like, we are all fucked.
torginus•Jun 30, 2026
Meanwhile in the real world, these Math Olympiad AIs can't even take your fast food order correctly.
cmiles8•Jun 30, 2026
Science isn’t suffering from a lack of papers. It’s suffering from a lack of good papers. Making it easier to just pump out paper-mill publications is about the last thing science needs right now.
godzillabrennus•Jun 30, 2026
Scientific research is suffering from a reproducibility crisis. Not a publication crisis. LLM's aren't going to solve reproducibility issues.
messh•Jun 30, 2026
They're gonna worsen it
ianm218•Jun 30, 2026
Isn't this just blanket cynicism?
In the long run conceivable we could use AI to hold papers to a much higher standard, audit all the data and code that is associated etc.
dag100•Jun 30, 2026
Unless reviewing becomes more profitable than publishing, anything that makes both easier will drive one up far more than the other. And it is difficult to conceive of something that would make reviewing much easier without making publishing much easier.
xpct•Jun 30, 2026
> audit all the data and code that is associated
For a while now there has been very little incentive for providing these alongside the paper, and I don't see why exactly 'AI' would change this. I could even see how making it vague to be harder to test with LLMs could be profitable for citation hackers.
mobeets•Jun 30, 2026
Por que no los dos? Scientific review times are up, it’s harder to find reviewers, and many reviews are AI generated anyway. Auto-generated research publications will arguably make the replication crisis worse, because there will be more slop to clog up the review system, and these papers will presumably be just as (if not more) not reproducible than human written science
cma•Jun 30, 2026
In some fields like comp sci, when code isn't given but the paper describes the approach, LLMs do help with the reproducibility crisis: you can ask it to reproduce the result through reimplementation by reading the paper.
If it fails you may have to double check it did properly reimplement it, but if it succeeds you do get a reproduction.
FeteCommuniste•Jun 30, 2026
The two feed into each other. "Publish or perish" ups the incentive to pump out shaky papers to pad resumes. LLMs make it easier to churn them out.
rolph•Jun 30, 2026
it could also be said that scientific interpretation is suffering from a framework crisis. the scientific convention of experiment, is the test of an hypothesis, as a logical construct.
repetition of materials and methods toward reproducibility, holds far less wieght than multiple variants of process designed to test a common hypothesis resulting in agreement.[null, or failure to null]
CJefferson•Jun 30, 2026
They are going to make it a thousands times worse.
It wasn't perfect before, but it at least took some time to fake a paper. The problem is now people can produce a very plausible looking completely fake paper in minutes. Peer review is in the process of completely collapsing, in fact I think it's already basically done.
The only way this might fix things is if we require all papers are completely reproducable (that doesn't help in subjects like biology of course. They can still provide all the experimental data in the rawest format possible which doesn't break any laws).
nok22kon•Jun 30, 2026
it's suffering from having 1 million researchers, when there aren't 1 million important easy problems to solve, yet you must publish something
virissimo•Jun 30, 2026
It seems to me that LLM's could massively improve reproducibility issues if journals would require that the papers be reproducible by model X using a standardized prompt in < N minutes, etc...
xpct•Jun 30, 2026
I'm actually quite excited for when (if) the models get good enough to start replicating compsci papers. I'd love it if there was a system which calculated a reproducibility score per-lab or per-researcher, which I could look up alongside their citation count.
I want to see who did the hard work properly, and who focused on publishing with concealed details.
dgfl•Jun 30, 2026
My hope is that the flood of AI articles pushes the academic publication system to its highly-anticipated breaking point.
The most absurd part is that everyone in academia knows that publish or perish is tremendously damaging to real research. Yet we’re all hostage of this system that we created in the name of “merit” and “efficiency”.
We need a different system to identify and reward talented hard-working people. Back in the day it all relied on actual interpersonal interaction and subjective judgment, but there were also much fewer researchers worldwide.
dag100•Jun 30, 2026
> My hope is that the flood of AI articles pushes the academic publication system to its highly-anticipated breaking point.
This will just make research inaccessible to most researchers. There is no incentive to limit publishing, at all, other than at the highest echelons. Publish or perish will just become worse. Look at what is happening to programming and extrapolate that to research work.
And all for what? Just to keep up this facade of society until most of society can be excised, whether artificially or naturally though lack of reproduction.
nickandbro•Jun 30, 2026
So I guess they released this instead of Sonnet 5?
tripleee•Jun 30, 2026
maxed out on coding improvements so now they're trying to expand to other markets
cma•Jun 30, 2026
Why have they talked about this for a long time? They predicted date of code maxing out, and did so not from fitting a sigmoid or something but they predicted it would max out right during a steep part of the slope?
raphman•Jun 30, 2026
tl;dr: Use this if you don't like doing science or doing things well. It hallucinates references.
Mostly targeted at life sciences - e.g. integration for FDA, PubMed, genomics databases but no ACM / IEEE as far as I can tell.
Edit: arXiv search seems to be supported - but not Google Scholar etc. So, this tool is of little use for most researchers outside life sciences.
Edit 2: Quick walkthrough: the AppImage starts a browser window with an onboarding wizard and a chat interface. It suggests a few things one might do at the start of a research project - e.g. do a quick literature review. When I chose that option, wrote Python scripts that used MCP calls to do arXiv searches. Stayed seemingly stuck there for a few minutes not returning anything. Then:
> The free-text search returned too much noise
Claude decided to choose a certain paper as a starting point for further research. Shortly afterwards:
> That DOI resolved to the wrong paper. Let me find the correct anchor papers by title/author search directly.
Then it meandered a few more minutes doing research and creating a citation graph (that it did not show to me).
> I have a complete picture. Let me verify the key DOIs resolve and then write the review.
Then:
> The lint flags em-dash overuse. Let me reduce them, then save.
Then: a nice but verbose literature overview of my chosen topic
<blink>BUT it includes at least one hallucinated reference!</blink>
P.S.: What does this mean?
[reviewer] verifier_mode=default-on downgraded to off: pro subscription tier, autoReviewer withheld (frame=f2a81cb2)
sampo•Jun 30, 2026
Biosciences mostly don't use arXiv, they have their own https://www.biorxiv.org/ but it's usage is not as common as arXiv is in e.g. physics.
Retr0id•Jun 30, 2026
> The lint flags em-dash overuse
An explicit text desloppification pass (i.e. LLM-use obfuscation) seems like outright scientific fraud.
sansseriff•Jun 30, 2026
It sure is! But ironically, because of the intention behind the obfuscation. Not the fact that AI was used in a research paper.
I have no issues with AI use in science. If claude can explain my research better than me, then have at it. But I do NOT want to read a passage thinking it was written by a human when it wasn't. Science has no idea yet how such disclosures should work yet. What should be done by humans as a matter of principle, and what can't be or should not be done by humans.
dleeftink•Jun 30, 2026
Some authors may even choose to leave syntactical errors as a tell for those self-authored passages; long-term, some interesting language drifts may come of it.
jvanderbot•Jun 30, 2026
Thought I'd give it a whirl - crashed immediately.
I was tickled they had a "Download for linux" button prominently shown, but nothing yet.
Sol-•Jun 30, 2026
So it's like Claude Cowork for Science, i.e. for less tech-savvy users? I would imagine scientists with some coding background might just prefer to use Claude Code normally and integrate it with their stack of choice, but perhaps the comfort and ease of use of Claude Science still wins out.
calldacopsidgaf•Jun 30, 2026
this a great application for the sycophantic, non-deterministic lying machine!
thrill•Jun 30, 2026
It's called Claude Science, not Claude Politician.
khurs•Jun 30, 2026
Big Pharama = Big Budgets.
So targeting them with a tailored product is understandable.
asdff•Jun 30, 2026
pharma is currently in a tailspin and not really spending money. they'd rather outsource everything possible to china or india right now.
minimaxir•Jun 30, 2026
When I saw "Science" I didn't think they meant Data Science, which is what the UIs full of pandas code and plots imply. Even if the focus is on the sciences, I suspect that's the less valuable part of the announcement particularly with the implication of Jupyter Notebook 2.0.
Image-understanding for data viz is a use case that has been ignored, and modern LLMs are getting better at proper EDA. But, uh, I may need to update my resume.
__MatrixMan__•Jun 30, 2026
My take based on the video is that they're thinking more about bioinformatics, which might technically fall under the "data science" umbrella depending how you define your terms, but which is not described that way in common usage.
It's the content that determines the sort of science, not the toolchain.
winwang•Jun 30, 2026
Honestly quite excited to see what can happen here, I think biology has generally had a lack of data science expertise.
ritzaco•Jun 30, 2026
A lot of the soft and hard sciences use hacky matplotlib code to produce results and visualisation, without being necessarily data science
From the bits I've seen, I'd take claude-generated code any time over that written by maths, physics, biology, linguistics people. Even though I've seen Claude make some super-big mistakes while doing data analysis I'd guess it's already more reliable than most academics trying to code.
beardedwizard•Jun 30, 2026
This 100000x over. Nothing is worse than trying to productionize code coming from academics like this.
quijoteuniv•Jun 30, 2026
All of these new things are starting to look like soviet space program propaganda. Is there something really new?
bozdemir•Jun 30, 2026
Another overrated packaged workspace to drain more usage... No thank you.
impressive to me, but sadly i feel a little misleading since this is only the data-science part of life sciences.
every few weeks though i test claude and chatgpt on their scientific reasoning and it has definitely improved over time. in my experience without specific instruction on what is known/unknown they typically are lagging behind the leading edge of the field (dev bio/pluripotency in my case). probably because scientific research articles are not open-source so they can't crawl them.
claude has definitely outperformed chatgpt in this regard however, it's scientific reasoning is impressive.
game_the0ry•Jun 30, 2026
Disappointing that science came after cowork. Shows how their priorities are for profitability first and help humanity second.
uejfiweun•Jun 30, 2026
Now this... this is a hot take. How exactly do you expect these companies to "help humanity" if they're bleeding money?
imdsm•Jun 30, 2026
Weird that it runs as a local webserver rather than as an app
unfortunately no arch based distro support. I'm curious why it's not packaged as a flatpak.
Recursing•Jun 30, 2026
Many deb packages are easily repackaged for arch by the community
arendtio•Jun 30, 2026
Well, for Arch Linux, there was the unofficial version from the official binary in the AUR already... (Not sure what you mean by 'no arch based distro support').
loufe•Jun 30, 2026
First party support would be nice since this is not a high-trust in the AUR period, but fair point, I'll probably use it, thank you!
lebovic•Jun 30, 2026
I built one of the connected tools included in this launch (the Biomni HPC [1]), and I have spent an inordinate amount of my life working on this problem. (I also worked at Anthropic, but not on this product.)
As other comments have pointed out, this is for data science – but it's capable of more than making plots and writing papers [2]. It has integrations with many databases and computational tools, including a researcher's institutional cluster.
That alone is valuable. I founded a startup after struggling with this problem at a bio startup; integrating these tools and databases is hard and time consuming. If the only outcome of this product is that great APIs are built for LLMs, it will be a massive positive impact. Many databases used in computational genomics are still only accessible through FTP!
LLMs are particularly good at navigating these tools and databases. It's often very specialized, but straightforward, work that benefits from in-context skills. Seeing an early glimpse of my former customers – bioinformaticians – using LLMs to solve this problem is what led me to join Anthropic in 2024.
Also, this pattern isn't fundamentally constrained to data science: you can also integrate with a wet lab or a CRO for some kinds of science. This is what I'm spending my time on now.
This type of science doesn't solve everything, but it's useful in some niches. For example, progress on many rare diseases is bottlenecked by researcher attention rather than a fundamental breakthrough.
[2] In comparison, OpenAI's science product – Prism – was effectively a LaTeX editor they acquired with Crixet.
aabhay•Jun 30, 2026
Can you speak to what makes this different from simply including or configuring various agent skills? Or is it simply the combination of lots of helpful defaults that makes this product useful?
Melatonic•Jun 30, 2026
Sounds like the perfect use case for some kind of framework where you have a local LLM (that can run on lower spec hardware) collaborating with the main LLM to optimise latency and all the other niche and legacy use cases ?
CamperBob2•Jun 30, 2026
Claude: "Not that science"
trallnag•Jun 30, 2026
"Pre-configured for your domain [...] cheminformatics" as in something like ChEMBL?
qwerty_clicks•Jun 30, 2026
Should be called Claude-bio-big-bucks.
What about earth science, physics, engineering? The connectors and skills are all just biology and pharma. Boo
brcmthrowaway•Jun 30, 2026
DoA
theplumber•Jun 30, 2026
They forgot to include an example of prompt error on “cancer” with Fable in that “nice” video.
fastaguy88•Jun 30, 2026
Download for mac. Find out I need a different subscription. Cannot quit program (must force quit).
26 Comments
> Anthropic @AnthropicAI Jun 27, 2026 · 12:29 AM UTC
> Since June 12, we’ve been working closely with the US government to restore access to Claude Mythos 5 and Fable 5. Today, the government notified us that Mythos 5, our strongest cybersecurity model, can be redeployed to a set of US organizations that operate and defend critical infrastructure.
> We’re restoring access for these organizations quickly, and we’re continuing to work with the government to expand access to Mythos 5 and make Fable 5 available for general use again.
Opus 4.8/ GPT 5.6 level models with the right workflows/ data/ access are still good enough to do huge amounts of economically valueable work.
AI brand identity has made the unfortunate pivot to "how much do you trust us" which is going be a real race to the bottom. I don't want LLMs managing nuclear reactors or replacing junior lab technicians. I don't trust any of these LLMs to do the bare minimum, regardless of how good it is for your brand.
It's gross watching these stunts unfold. Next ChatGPT will fly a passenger jet, which Claude will one-up with an agentic surgery, which OpenAI will respond to by putting a humanoid robot on the moon. If this is what 21st century market competition looks like, we are all fucked.
In the long run conceivable we could use AI to hold papers to a much higher standard, audit all the data and code that is associated etc.
For a while now there has been very little incentive for providing these alongside the paper, and I don't see why exactly 'AI' would change this. I could even see how making it vague to be harder to test with LLMs could be profitable for citation hackers.
If it fails you may have to double check it did properly reimplement it, but if it succeeds you do get a reproduction.
repetition of materials and methods toward reproducibility, holds far less wieght than multiple variants of process designed to test a common hypothesis resulting in agreement.[null, or failure to null]
It wasn't perfect before, but it at least took some time to fake a paper. The problem is now people can produce a very plausible looking completely fake paper in minutes. Peer review is in the process of completely collapsing, in fact I think it's already basically done.
The only way this might fix things is if we require all papers are completely reproducable (that doesn't help in subjects like biology of course. They can still provide all the experimental data in the rawest format possible which doesn't break any laws).
I want to see who did the hard work properly, and who focused on publishing with concealed details.
The most absurd part is that everyone in academia knows that publish or perish is tremendously damaging to real research. Yet we’re all hostage of this system that we created in the name of “merit” and “efficiency”.
We need a different system to identify and reward talented hard-working people. Back in the day it all relied on actual interpersonal interaction and subjective judgment, but there were also much fewer researchers worldwide.
This will just make research inaccessible to most researchers. There is no incentive to limit publishing, at all, other than at the highest echelons. Publish or perish will just become worse. Look at what is happening to programming and extrapolate that to research work.
And all for what? Just to keep up this facade of society until most of society can be excised, whether artificially or naturally though lack of reproduction.
Seems to be based on https://github.com/swaruplab/operon as evidenced by the authorization dialog and https://x.com/testingcatalog/status/2037684573161783373 .
Mostly targeted at life sciences - e.g. integration for FDA, PubMed, genomics databases but no ACM / IEEE as far as I can tell.
Edit: arXiv search seems to be supported - but not Google Scholar etc. So, this tool is of little use for most researchers outside life sciences.
Edit 2: Quick walkthrough: the AppImage starts a browser window with an onboarding wizard and a chat interface. It suggests a few things one might do at the start of a research project - e.g. do a quick literature review. When I chose that option, wrote Python scripts that used MCP calls to do arXiv searches. Stayed seemingly stuck there for a few minutes not returning anything. Then:
> The free-text search returned too much noise
Claude decided to choose a certain paper as a starting point for further research. Shortly afterwards:
> That DOI resolved to the wrong paper. Let me find the correct anchor papers by title/author search directly.
Then it meandered a few more minutes doing research and creating a citation graph (that it did not show to me).
> I have a complete picture. Let me verify the key DOIs resolve and then write the review.
Then:
> The lint flags em-dash overuse. Let me reduce them, then save.
Then: a nice but verbose literature overview of my chosen topic
<blink>BUT it includes at least one hallucinated reference!</blink>
P.S.: What does this mean?
An explicit text desloppification pass (i.e. LLM-use obfuscation) seems like outright scientific fraud.
I have no issues with AI use in science. If claude can explain my research better than me, then have at it. But I do NOT want to read a passage thinking it was written by a human when it wasn't. Science has no idea yet how such disclosures should work yet. What should be done by humans as a matter of principle, and what can't be or should not be done by humans.
I was tickled they had a "Download for linux" button prominently shown, but nothing yet.
So targeting them with a tailored product is understandable.
Image-understanding for data viz is a use case that has been ignored, and modern LLMs are getting better at proper EDA. But, uh, I may need to update my resume.
It's the content that determines the sort of science, not the toolchain.
From the bits I've seen, I'd take claude-generated code any time over that written by maths, physics, biology, linguistics people. Even though I've seen Claude make some super-big mistakes while doing data analysis I'd guess it's already more reliable than most academics trying to code.
every few weeks though i test claude and chatgpt on their scientific reasoning and it has definitely improved over time. in my experience without specific instruction on what is known/unknown they typically are lagging behind the leading edge of the field (dev bio/pluripotency in my case). probably because scientific research articles are not open-source so they can't crawl them.
claude has definitely outperformed chatgpt in this regard however, it's scientific reasoning is impressive.
Claude Sonnet 5
https://news.ycombinator.com/item?id=48736605
Do they have no shame?
Edit: seems like no https://news.ycombinator.com/item?id=48736814
As other comments have pointed out, this is for data science – but it's capable of more than making plots and writing papers [2]. It has integrations with many databases and computational tools, including a researcher's institutional cluster.
That alone is valuable. I founded a startup after struggling with this problem at a bio startup; integrating these tools and databases is hard and time consuming. If the only outcome of this product is that great APIs are built for LLMs, it will be a massive positive impact. Many databases used in computational genomics are still only accessible through FTP!
LLMs are particularly good at navigating these tools and databases. It's often very specialized, but straightforward, work that benefits from in-context skills. Seeing an early glimpse of my former customers – bioinformaticians – using LLMs to solve this problem is what led me to join Anthropic in 2024.
Also, this pattern isn't fundamentally constrained to data science: you can also integrate with a wet lab or a CRO for some kinds of science. This is what I'm spending my time on now.
This type of science doesn't solve everything, but it's useful in some niches. For example, progress on many rare diseases is bottlenecked by researcher attention rather than a fundamental breakthrough.
[1] https://x.com/phylo_bio/article/2029233694775624096
[2] In comparison, OpenAI's science product – Prism – was effectively a LaTeX editor they acquired with Crixet.
What about earth science, physics, engineering? The connectors and skills are all just biology and pharma. Boo
Perhaps I need AI to use it.